Eicosapentaenoic acid limits the more rapid oxidation of lipoprotein(a) compared with other apolipoprotein B particles
Lp(a)-enriched plasma underwent more rapid oxidation than other ApoB-containing lipoproteins and promoted inflammatory changes in EC protein expression, a process attenuated by EPA. This action may contribute to reduced CV risk by EPA in those with elevated Lp(a) levels.
Authors
- Deepak L. Bhatt (ORCID: https://orcid.org/0000-0002-1278-6245)
- Samuel Sherratt (ORCID: https://orcid.org/0000-0002-0913-2865)
- Peter Libby (ORCID: https://orcid.org/0000-0002-1502-502X)
- Richard L. Dunbar (ORCID: https://orcid.org/0000-0002-7059-4794)
- R. Preston Mason (ORCID: https://orcid.org/0000-0001-5483-1852)
Institutions
- Brigham and Women's Hospital (US)
- Harvard University (US)
- Mount Sinai Hospital (US)
- Cummings Foundation (US)
- Bridge Pharma (United States) (US)
- Icahn School of Medicine at Mount Sinai (US)
Publication Details
- Journal
- Cardiovascular Research
- Published
- 2025-08-22
- DOI
- https://doi.org/10.1093/cvr/cvaf144
- Primary Topic
- Lipoproteins and Cardiovascular Health
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Amarin Corporation
- Amarin Pharma