Integrated pan-cancer analysis of RNA binding protein HuR investigates its biomarker potential in prognosis, immunotherapy, and drug sensitivity
Our pan-cancer analysis establishes HuR as a consistently upregulated oncogenic driver across malignancies, functioning as a potential universal biomarker for prognosis and diagnosis. Its critical roles in modulating the immune response and predicting therapeutic sensitivity highlight its importance for personalized cancer treatment strategies. HuR orchestrates tumorigenesis and malignant progression by integrally regulating vital cellular processes.
Authors
- Xiaoru Wang (ORCID: https://orcid.org/0000-0002-6150-7046)
- Jichuan Quan
- Jian Peng (ORCID: https://orcid.org/0009-0009-6780-4330)
Institutions
- Shanxi Medical University (CN)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Second Hospital of Shanxi Medical University (CN)
- Anhui Provincial Children's Hospital (CN)
Publication Details
- Journal
- PLoS Computational Biology
- Published
- 2025-08-25
- DOI
- https://doi.org/10.1371/journal.pcbi.1013374
- Primary Topic
- RNA modifications and cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Health Commission of Shanxi Province