Integrated pan-cancer analysis of RNA binding protein HuR investigates its biomarker potential in prognosis, immunotherapy, and drug sensitivity

Our pan-cancer analysis establishes HuR as a consistently upregulated oncogenic driver across malignancies, functioning as a potential universal biomarker for prognosis and diagnosis. Its critical roles in modulating the immune response and predicting therapeutic sensitivity highlight its importance for personalized cancer treatment strategies. HuR orchestrates tumorigenesis and malignant progression by integrally regulating vital cellular processes.

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Publication Details

Journal
PLoS Computational Biology
Published
2025-08-25
DOI
https://doi.org/10.1371/journal.pcbi.1013374
Primary Topic
RNA modifications and cancer
Type
article
Field-Weighted Citation Impact
0.00

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article

Integrated pan-cancer analysis of RNA binding protein HuR investigates its biomarker potential in prognosis, immunotherapy, and drug sensitivity

Xiaoru Wang, Jichuan Quan, Jian Peng
1 links
PLoS Computational Biology
RNA modifications and cancer
article

Integrated pan-cancer analysis of RNA binding protein HuR investigates its biomarker potential in prognosis, immunotherapy, and drug sensitivity

Xiaoru Wang, Jichuan Quan, Jian Peng
article en

Abstract

Our pan-cancer analysis establishes HuR as a consistently upregulated oncogenic driver across malignancies, functioning as a potential universal biomarker for prognosis and diagnosis. Its critical roles in modulating the immune response and predicting therapeutic sensitivity highlight its importance for personalized cancer treatment strategies. HuR orchestrates tumorigenesis and malignant progression by integrally regulating vital cellular processes.

PLoS Computational BiologyVol. 21(8)
Shanxi Medical University (CN), Chinese Academy of Medical Sciences & Peking Union Medical College (CN), Second Hospital of Shanxi Medical University (CN), Anhui Provincial Children's Hospital (CN)
Health Commission of Shanxi Province
Openalex Percentile: Top 80%
RNA modifications and cancer
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