Shared decision-making and deprescribing to support anti-thrombotic therapy (dis)continuance for persons living with cancer in their last phase of life: A realist synthesis
Implementation of ATT deprescribing is enabled or constrained by (a) the meaning of medications to patients; (b) clinician engagement and understanding; (c) multi-disciplinary clinical decision-making processes (including support tools); (d) patient empowerment; (e) organizational investment. Addressing these multi-level factors, including the development of SDM tools, can address the prescribing inertia that may cause devastating impacts on patients and their families as well as moral distress amongst healthcare staff. This study was performed as part of the Horizon-Europe funded SERENITY project.
Authors
- Justin Jagosh (ORCID: https://orcid.org/0000-0001-6807-2957)
- Fliss EM Murtagh (ORCID: https://orcid.org/0000-0003-1289-3726)
- Mark Pearson (ORCID: https://orcid.org/0000-0001-7628-7421)
- Eric C. T. Geijteman (ORCID: https://orcid.org/0000-0001-7354-2220)
- Anette Arbjerg Højen (ORCID: https://orcid.org/0000-0002-3851-3069)
- Adrian Edwards (ORCID: https://orcid.org/0000-0001-7432-2828)
- Adrian Edwards (ORCID: https://orcid.org/0000-0002-6228-4446)
- Frederikus Albertus Klok (ORCID: https://orcid.org/0000-0001-9961-0754)
- Anthony Maraveyas (ORCID: https://orcid.org/0000-0003-4176-5176)
- Kathy Seddon
- Simon Noble (ORCID: https://orcid.org/0000-0001-5425-2383)
- Miriam J. Johnson (ORCID: https://orcid.org/0000-0001-6204-9158)
- Gamze Keser
- Sarah Greenley (ORCID: https://orcid.org/0000-0002-3788-6437)
- Simon P. Mooijaart (ORCID: https://orcid.org/0000-0003-3106-3568)
Institutions
- University of Hull (GB)
- Aalborg University Hospital (DK)
- Leiden University Medical Center (NL)
- Erasmus MC Cancer Institute (NL)
- Hull York Medical School (GB)
- Cardiff University (GB)
- Aalborg University (DK)
Publication Details
- Journal
- PLoS Medicine
- Published
- 2025-08-25
- DOI
- https://doi.org/10.1371/journal.pmed.1004663
- Citations
- 3
- Primary Topic
- Patient-Provider Communication in Healthcare
- Type
- article
- Field-Weighted Citation Impact
- 8.45
Funders
- UK Research and Innovation
- National Institute for Health and Care Research
- Department of Health and Social Care
- European Commission
- Cardiff University
- HORIZON EUROPE Framework Programme