Detection of Human Brain Cancers using Genomic and Immune Cell Characterization of Cerebrospinal Fluid through CSF-BAM
There is a paucity of technologies beyond surgical biopsy that can accurately diagnose central nervous system neoplasms. We developed a novel, sensitive, and highly specific assay that can detect brain cancers by comprehensively identifying somatic mutations, chromosomal copy-number changes, and adaptive immunoreceptor repertoires from samples of CSF. See related commentary by Weiss, p. 1976.
Authors
- Carl Koschmann (ORCID: https://orcid.org/0000-0002-0825-7615)
- David Kamson (ORCID: https://orcid.org/0000-0002-0473-658X)
- Eric M. Jackson (ORCID: https://orcid.org/0000-0001-9306-9290)
- Debraj Mukherjee (ORCID: https://orcid.org/0000-0002-5403-8237)
- Michael Lim (ORCID: https://orcid.org/0000-0003-0523-3076)
- Lisa Dobbyn (ORCID: https://orcid.org/0000-0002-3159-189X)
- Megan Parker (ORCID: https://orcid.org/0000-0002-1096-9662)
- Natalie Silliman (ORCID: https://orcid.org/0000-0002-5198-9037)
- Mari L. Groves (ORCID: https://orcid.org/0000-0002-4938-897X)
- Christopher M. Jackson (ORCID: https://orcid.org/0000-0002-5958-2004)
- Alexander H. Pearlman (ORCID: https://orcid.org/0000-0002-3504-7517)
- Joshua D. Cohen (ORCID: https://orcid.org/0000-0003-1158-5668)
- Christopher Douville (ORCID: https://orcid.org/0000-0002-2510-4151)
- Janine Ptak (ORCID: https://orcid.org/0000-0003-1934-8739)
- Sima Rozati (ORCID: https://orcid.org/0000-0001-6318-6429)
- Kathy Judge
- Carlos A. Pardo (ORCID: https://orcid.org/0000-0002-4128-5335)
- George I. Jallo (ORCID: https://orcid.org/0000-0001-9607-6867)
- Nickolas Papadopoulos (ORCID: https://orcid.org/0000-0001-7135-7451)
- Melanie Alfonzo Horowitz (ORCID: https://orcid.org/0000-0002-4935-7268)
- Jarushka Naidoo (ORCID: https://orcid.org/0000-0002-3470-8686)
- Maria Popoli (ORCID: https://orcid.org/0000-0003-2151-7749)
- Maximilian F. Konig (ORCID: https://orcid.org/0000-0001-5045-5255)
- Anita Kalluri
- Suman Paul (ORCID: https://orcid.org/0000-0001-9357-3702)
- Alireza Mansouri (ORCID: https://orcid.org/0000-0002-7442-7539)
- John N. Theodore (ORCID: https://orcid.org/0009-0004-1901-3503)
- Kenneth W. Kinzler (ORCID: https://orcid.org/0000-0001-5591-1176)
- Jordina Rincón-Torroella (ORCID: https://orcid.org/0000-0003-4798-8231)
- Karisa C. Schreck (ORCID: https://orcid.org/0000-0001-7181-3269)
- Peter A. Calabresi (ORCID: https://orcid.org/0000-0002-7776-6472)
- Yuanxuan Xia (ORCID: https://orcid.org/0000-0001-6152-8392)
- M. Luciano (ORCID: https://orcid.org/0000-0002-5664-2956)
- Cole Sterling (ORCID: https://orcid.org/0000-0002-5911-3873)
- Chetan Bettegowda (ORCID: https://orcid.org/0000-0001-9991-7123)
- Michael Glantz (ORCID: https://orcid.org/0000-0003-4877-5094)
- Bert Vogelstein (ORCID: https://orcid.org/0000-0003-0766-3854)
- Jonathan C. Dudley (ORCID: https://orcid.org/0000-0002-5809-5538)
- Matthias Holdhoff (ORCID: https://orcid.org/0000-0002-3285-3484)
- Ryan Gensler (ORCID: https://orcid.org/0000-0001-8262-8405)
- Yuxuan Wang (ORCID: https://orcid.org/0000-0002-2932-6042)
- Jon Weingart
Institutions
- Howard Hughes Medical Institute (US)
- Johns Hopkins University (US)
- Palo Alto University (US)
- University of Michigan (US)
- Johns Hopkins Medicine (US)
- Beaumont Hospital (IE)
- Johns Hopkins All Children's Hospital (US)
- Sidney Kimmel Cancer Center (US)
- Michigan Medicine (US)
- Ludwig Cancer Research (US)
- Sidney Kimmel Comprehensive Cancer Center (US)
- Penn State Milton S. Hershey Medical Center (US)
- Stanford University (US)
Publication Details
- Journal
- Cancer Discovery
- Published
- 2025-08-25
- DOI
- https://doi.org/10.1158/2159-8290.cd-24-1788
- Citations
- 2
- Primary Topic
- Single-cell and spatial transcriptomics
- Type
- article
- Field-Weighted Citation Impact
- 1.61