Evidence for Systemic Perioperative Antibiotic Prophylaxis for Prevention of Fracture-related Infections Following Open Fractures: Systematic Review and Meta-Analysis of Randomized, Controlled, Clinical Trials
Although data were derived primarily from older studies, we summarized the strongest available evidence from RCTs for antibiotic prophylaxis following Gustilo-Anderson types I, I/II, II, III, and I/II/III, for upper and lower extremity open fractures, isolated upper extremity open fractures, and isolated lower extremity open fractures.
Authors
- Gregory J. Della Rocca (ORCID: https://orcid.org/0000-0003-2229-9966)
- Christopher S. Klifto (ORCID: https://orcid.org/0000-0001-8046-2085)
- Mark J. Gage (ORCID: https://orcid.org/0000-0002-7410-7850)
- Kevin M. Klifto (ORCID: https://orcid.org/0000-0002-2742-4319)
- Lily R. Mundy (ORCID: https://orcid.org/0000-0003-4821-1424)
- Suhail K. Mithani (ORCID: https://orcid.org/0000-0002-3762-0831)
Institutions
- University of Maryland, Baltimore (US)
- Johns Hopkins University (US)
- Duke University (US)
- Medical Protective (US)
- Kleijnen Systematic Reviews (United Kingdom) (GB)
- Centre Alpien de Phytogéographie (CH)
Publication Details
- Journal
- Journal of the American Academy of Orthopaedic Surgeons
- Published
- 2025-08-15
- DOI
- https://doi.org/10.5435/jaaos-d-24-00961
- Primary Topic
- Bone fractures and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00