A novel peptide‐fentanyl conjugate with μ‐opioid and neuropeptide FF receptor agonism produces antinociception with limited side effects in male mice
The newly developed peptide-drug conjugate FENPFF01 exhibited strong antinociception with reduced opioid-like side effects. It represents an interesting candidate for developing novel analgesics with multi-targeted agonist properties, aiming to address the widespread issues associated with opioid misuse.
Authors
- H. Zhao
- Wenqi Yan (ORCID: https://orcid.org/0000-0001-9603-048X)
- Feiyun Gao
- Biao Xu (ORCID: https://orcid.org/0000-0002-0686-1536)
- Quan Fang (ORCID: https://orcid.org/0000-0003-0381-6796)
- Mengna Zhang
- Nan Zhang (ORCID: https://orcid.org/0000-0002-9675-5322)
- Ning Li (ORCID: https://orcid.org/0000-0002-6518-2541)
- Zhenyun Yang
- Kangtai Xu (ORCID: https://orcid.org/0009-0006-8462-6212)
Institutions
- Lanzhou University (CN)
Publication Details
- Journal
- British Journal of Pharmacology
- Published
- 2025-08-25
- DOI
- https://doi.org/10.1111/bph.70178
- Citations
- 3
- Primary Topic
- Pain Mechanisms and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 3.49
Funders
- National Natural Science Foundation of China
- Fundamental Research Funds for the Central Universities