A rare case of late chromophobe RCC metastasis with indolent course

Renal cell carcinoma (RCC) is the predominant solid lesion of the kidney. Among the various subtypes of RCC, chromophobe RCC (chRCC) is relatively rare, and it is characterized by an indolent clinical course and a favourable prognosis. We present a rare case of a 40-year-old patient who developed a retroperitoneal metastasis four years after undergoing radical nephrectomy for chRCC. The patient was under surveillance for another six years before surgical excision of the recurrence was performed. This case underscores the potential for late recurrence in chRCC and highlights the importance of long-term surveillance, even in patients with an initially favourable prognosis.

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Publication Details

Journal
Urology Case Reports
Published
2025-08-25
DOI
https://doi.org/10.1016/j.eucr.2025.103180
Primary Topic
Renal cell carcinoma treatment
Type
article
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article

A rare case of late chromophobe RCC metastasis with indolent course

C Kalfountzos, P. Panagopoulos, Spyridon Davakis, Konstantinos Douroumis et al.
Urology Case Reports
Renal cell carcinoma treatment
article

A rare case of late chromophobe RCC metastasis with indolent course

C Kalfountzos, P. Panagopoulos, Spyridon Davakis, Konstantinos Douroumis, Periklis Anastasiou, Panagiotis Katsikatsos, Ιoannis Anastasiou
article en

Abstract

Renal cell carcinoma (RCC) is the predominant solid lesion of the kidney. Among the various subtypes of RCC, chromophobe RCC (chRCC) is relatively rare, and it is characterized by an indolent clinical course and a favourable prognosis. We present a rare case of a 40-year-old patient who developed a retroperitoneal metastasis four years after undergoing radical nephrectomy for chRCC. The patient was under surveillance for another six years before surgical excision of the recurrence was performed. This case underscores the potential for late recurrence in chRCC and highlights the importance of long-term surveillance, even in patients with an initially favourable prognosis.

Urology Case ReportsVol. 63
University of Ioannina (GR), National and Kapodistrian University of Athens (GR)
Zero hunger
Openalex Percentile: Top 67%
Renal cell carcinoma treatment
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