Recombinant human thrombopoietin improves hematopoietic stem cell differentiation and T-cell immune homeostasis in patients with severe aplastic anemia by upregulating c-MPL
rhTPO can induce the upregulation of c-MPL expression on HSCs, CD4<sup>+</sup> T cells, and Tregs in patients with SAA. It accelerates platelet production and regulates the proliferation of CD4<sup>+</sup> T cells and Tregs, thereby promoting immune homeostasis restoration in SAA.
Authors
- Chunyan Liu (ORCID: https://orcid.org/0000-0002-9194-5290)
- Rong Fu (ORCID: https://orcid.org/0000-0002-9928-9224)
- Chenchen Liu (ORCID: https://orcid.org/0000-0001-7228-6616)
- Ling Deng (ORCID: https://orcid.org/0000-0003-1355-8102)
- Yilin Guo (ORCID: https://orcid.org/0009-0007-8410-2328)
Institutions
- Tianjin Medical University General Hospital (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-08-25
- DOI
- https://doi.org/10.3389/fphar.2025.1542837
- Primary Topic
- Platelet Disorders and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Tianjin Municipal Health Commission
- National Natural Science Foundation of China
- Tianjin Medical University
- Tianjin Municipal Education Commission
- Tianjin Science and Technology Program