Prognostic impact of gene alterations via homologous recombination DNA repair gene alteration status in pancreatic ductal adenocarcinoma
HRR-altered PDAC has a distinct genomic profile and is associated with a favorable prognosis. Our findings demonstrate that coexisting alterations are significant prognostic factors in both HRR-altered and HRR-wild-type tumors. These results highlight the clinical relevance of incorporating comprehensive genomic profiling into routine care to stratify patient prognosis better and inform individualized treatment strategies in PDAC.
Authors
- Hisato Kawakami (ORCID: https://orcid.org/0000-0002-3280-4850)
- Yasutaka Chiba (ORCID: https://orcid.org/0000-0002-7261-2351)
- Masaki Okura
- Chiaki Inagaki (ORCID: https://orcid.org/0000-0003-1282-232X)
- Kimio Yonesaka (ORCID: https://orcid.org/0000-0002-0816-5315)
- Yusuke Kawanaka (ORCID: https://orcid.org/0000-0001-8494-4970)
- Kazuhiko Nakagawa
- Takayuki Takahama (ORCID: https://orcid.org/0000-0002-0321-6718)
- Seiichiro Mitani (ORCID: https://orcid.org/0000-0003-0033-8741)
- Hidetoshi Hayashi (ORCID: https://orcid.org/0000-0002-3049-9143)
Institutions
- Tohoku University (JP)
- Kindai University Hospital (JP)
- Kindai University (JP)
Publication Details
- Journal
- Frontiers in Medicine
- Published
- 2025-08-25
- DOI
- https://doi.org/10.3389/fmed.2025.1570731
- Citations
- 1
- Primary Topic
- Pancreatic and Hepatic Oncology Research
- Type
- article
- Field-Weighted Citation Impact
- 1.05
Funders
- Kindai University
- Kanazawa University