Slapping automatism in epileptic seizures: a case series
SEEG recordings in this study confirm a strong association between orbitofrontal lobe epileptic activity and slapping automatism. Notably, we report a case of TLE with comorbid OCD, characterized by frequent epileptiform discharges in the orbitofrontal lobe, providing direct electrophysiological evidence of prefrontal abnormalities in OCD. Together, these findings highlight a shared pathological network of orbitofrontal-striatal-pallidal-thalamic between frontal and temporal epilepsy with slapping automatism and OCD.
Authors
- Shikun Zhan
- Ziyi Feng (ORCID: https://orcid.org/0000-0001-6113-5097)
- Chunyan Cao (ORCID: https://orcid.org/0000-0001-8324-8199)
- Qiang Zhou (ORCID: https://orcid.org/0000-0001-7099-1995)
- Bomin Sun (ORCID: https://orcid.org/0000-0001-5931-2197)
- Wei Liu (ORCID: https://orcid.org/0000-0003-0508-4605)
- Haifeng Zhao (ORCID: https://orcid.org/0000-0002-7306-3024)
- Shenglin Hao (ORCID: https://orcid.org/0000-0003-0831-3493)
Institutions
- Second Military Medical University (CN)
- Ruijin Hospital (CN)
- Shanghai Pudong New Area Gongli Hospital (CN)
Publication Details
- Journal
- Frontiers in Human Neuroscience
- Published
- 2025-08-25
- DOI
- https://doi.org/10.3389/fnhum.2025.1593597
- Primary Topic
- Obsessive-Compulsive Spectrum Disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- University College London
- National Natural Science Foundation of China
- Shanghai Jiao Tong University
- Ruijin Hospital