Association of early acetaminophen administration with mortality in surgical intensive care patients: a retrospective cohort study
Early acetaminophen administration demonstrates independent associations with reduced in-hospital mortality and improved secondary clinical outcomes in surgical ICU populations. These findings highlight the need for prospective trials to confirm therapeutic efficacy and establish causal inference for this readily available pharmacologic intervention.
Authors
- Hanli Chen
- Min Zhong (ORCID: https://orcid.org/0000-0002-8759-7983)
- Ziyang Wang (ORCID: https://orcid.org/0000-0001-6130-6212)
- Jian Wu (ORCID: https://orcid.org/0000-0002-3394-1507)
- Yihao Li (ORCID: https://orcid.org/0000-0003-1900-8099)
- Jiajing Li (ORCID: https://orcid.org/0000-0001-5298-8637)
- Yongyong Shi (ORCID: https://orcid.org/0000-0002-1899-8126)
Institutions
- Guangzhou University of Chinese Medicine (CN)
- Second Affiliated Hospital of Guangzhou Medical University (CN)
- Guangzhou Medical University (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-08-25
- DOI
- https://doi.org/10.3389/fphar.2025.1588978
- Primary Topic
- Intensive Care Unit Cognitive Disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Guangdong Provincial Hospital of Traditional Chinese Medicine