Association between copper exposure and renal fibrosis in patients with chronic kidney disease: evidence from Mendelian randomization and a retrospective study
Elevated serum copper is independently associated with renal fibrosis in CKD, suggesting copper dysregulation may contribute to fibrotic pathogenesis. These findings underscore the therapeutic potential of targeting copper metabolism to mitigate CKD progression.
Authors
- Zhengwei Wan (ORCID: https://orcid.org/0000-0002-4239-0882)
- Guisen Li (ORCID: https://orcid.org/0000-0003-1970-9979)
- Honghua Hu (ORCID: https://orcid.org/0000-0002-3749-4089)
- Ping Shuai (ORCID: https://orcid.org/0000-0001-5857-0186)
- Xiang Zhong (ORCID: https://orcid.org/0000-0003-3585-4201)
- Li Wang (ORCID: https://orcid.org/0000-0003-3881-3149)
- Ting Wang (ORCID: https://orcid.org/0000-0002-1309-0194)
- Min Yu (ORCID: https://orcid.org/0000-0003-1875-740X)
- Yongjun He (ORCID: https://orcid.org/0000-0002-2697-5012)
- Kaixiang Liu (ORCID: https://orcid.org/0000-0002-8053-4701)
- Shasha Chen
Institutions
- University of Electronic Science and Technology of China (CN)
Publication Details
- Journal
- Frontiers in Public Health
- Published
- 2025-08-25
- DOI
- https://doi.org/10.3389/fpubh.2025.1657180
- Citations
- 1
- Primary Topic
- Trace Elements in Health
- Type
- article
- Field-Weighted Citation Impact
- 1.12
Funders
- National Natural Science Foundation of China