Glycan dysregulation as one of major metabolic subtypes is associated with TERC overexpression and poor outcomes in cervical cancer
Metabolic heterogeneity occurs substantially in CCs and glycan dysregulation is associated with the shortest DFS in CCs. Specifically, the combination of GRGM-3 scores with TERC expression identifies patients with the poorest outcomes, providing a potential tool for individualized risk assessment and contributing to CC precision medicine. It is worth validating our findings for potential clinical application.
Authors
- Yu Wu (ORCID: https://orcid.org/0000-0002-9964-4898)
- Qingzhen Hou (ORCID: https://orcid.org/0000-0002-7655-0899)
- Yunhai Yu (ORCID: https://orcid.org/0000-0002-4511-8999)
- Dawei Xu (ORCID: https://orcid.org/0000-0003-3141-4524)
- Xing Shi (ORCID: https://orcid.org/0000-0002-0622-1395)
- Lina Wang (ORCID: https://orcid.org/0000-0002-1619-3957)
- Xinyuan Zhang (ORCID: https://orcid.org/0000-0003-3693-3374)
- Jingjie Zhao
- Yanlei Dong
Institutions
- Karolinska University Hospital (SE)
- Shandong University (CN)
- Second Hospital of Shandong University (CN)
- Liaocheng People's Hospital (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-08-25
- DOI
- https://doi.org/10.3389/fimmu.2025.1585647
- Primary Topic
- Cervical Cancer and HPV Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Natural Science Foundation of Shandong Province