Crab shell polypeptides enhance calcium dynamics and osteogenic activity in osteoporosis
Our findings position SCSP as a promising natural therapeutic for OP and provide key mechanistic insights that may guide future bone-targeted interventions.
Authors
- Guangmin Zhang (ORCID: https://orcid.org/0000-0002-7686-8194)
- Xiangzhong Zhao (ORCID: https://orcid.org/0000-0002-8064-066X)
- Chong Sun (ORCID: https://orcid.org/0000-0001-9008-2158)
- Jiane Liu
- Daijie Wang (ORCID: https://orcid.org/0000-0002-2156-4548)
- Hui Zhang (ORCID: https://orcid.org/0000-0002-6355-5404)
- Yiming Zhang (ORCID: https://orcid.org/0000-0001-9603-2362)
- Zheng Wang (ORCID: https://orcid.org/0000-0002-7909-4796)
- Linlin Liu (ORCID: https://orcid.org/0000-0002-1784-239X)
- Bing Li (ORCID: https://orcid.org/0000-0002-7041-6701)
- Xinlei Li (ORCID: https://orcid.org/0000-0002-9294-0459)
- Shaoqi Tian (ORCID: https://orcid.org/0000-0002-2202-3604)
- Xiaohui Xu
- Jinpeng Zhen
- Xiaolei Dong
Institutions
- Qingdao University (CN)
- Shandong University of Traditional Chinese Medicine (CN)
- Qilu University of Technology (CN)
- Affiliated Hospital of Qingdao University (CN)
- Shandong Academy of Sciences (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-08-25
- DOI
- https://doi.org/10.3389/fphar.2025.1605422
- Primary Topic
- Bone Metabolism and Diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Taishan Scholar Foundation of Shandong Province
- National Natural Science Foundation of China
- Natural Science Foundation of Shandong Province
- Shandong Academy of Sciences
- Qingdao University
- Qilu University of Technology