Risk of developing juvenile idiopathic arthritis after quadrivalent HPV vaccination: a retrospective cohort study using the TriNetX U.S. Network
Our findings suggest that HPV4 vaccination is not associated with an increased risk of JIA. On the contrary, vaccination may confer a long-term protective effect against new-onset JIA, observable from 6-12 months and lasting for at least 3 years. These findings support the safety and possible immunoregulatory benefit of HPV4 in adolescents.
Authors
- Junpeng Chen (ORCID: https://orcid.org/0000-0003-2307-6406)
- Hsin‐Hua Chen (ORCID: https://orcid.org/0000-0002-7304-4587)
- Ming-Chin Tsai (ORCID: https://orcid.org/0000-0002-7206-4228)
- Lin‐Shien Fu
- Yung‐Chieh Huang (ORCID: https://orcid.org/0000-0003-2945-4404)
- Wenyu Wu (ORCID: https://orcid.org/0000-0001-9365-684X)
Institutions
- National Yang Ming Chiao Tung University (TW)
- National Chung Hsing University (TW)
- Taichung Veterans General Hospital (TW)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-08-25
- DOI
- https://doi.org/10.3389/fimmu.2025.1621939
- Primary Topic
- Rheumatoid Arthritis Research and Therapies
- Type
- article
- Field-Weighted Citation Impact
- 0.00