Comparative study of the quantitative content of diterpene compounds in the leaves of some species of the genus <i>Salvia</i> L.

Aim – to conduct a comparative quantitative analysis of diterpene compounds in the leaves of some species of the genus Salvia L. native to the Samara region. Material and methods. The studied samples are the leaves of Salvia officinalis L., leaves of Salvia nemorosa L., leaves of Salvia verticillata L., leaves of Salvia nutans L. and leaves of Salvia dumetorum Andrz. ex Besser. Quantitative determination of diterpene compounds was carried out according to the method of RAS Professor I.N. Zilfiqarov using a working standard sample of carnosolic acid purchased from the pharmaceutical company Wuhan HengHeDa Pharm Co (Wuhan, People’s Republic of China). The content of the sum of diterpenic acids in terms of carnosolic acid was determined by the spectral method using the specific absorption index of the standard sample equal to 49.84. Results. A quantitative analysis was performed to determine the amount of diterpenic acids in terms of carnosolic acid in the leaves of Salvia officinalis L., leaves of Salvia nemorosa L., leaves of Salvia verticillata L., leaves of Salvia nutans L. and leaves of Salvia dumetorum Andrz. ex Besser. The maximum value of diterpenes was found in the leaves of Salvia officinalis L. (1.38±0.02%). Conclusion. The results obtained during the study will contribute to the improvement of the “Quantitative determination” section of the pharmacopoeial article of the FS.2.5.0051.15 Salviae officinalis folia, as well as the development of regulatory documentation for the raw materials of the studied species of the genus Salvia L.