Effect of clonal hematopoiesis on plaque morphology and prognosis in patients with acute myocardial infarction
TET2/ASXL1 CHIP mutations with VAF > 2% combined with high inflammatory status were indicative of high mortality in patients with STEMI. Additionally, TET2/ASXL1 mutation with a VAF > 0.5% favored the recognition of vulnerable plaque features in patients with STEMI.
Authors
- Peng Zhou (ORCID: https://orcid.org/0000-0002-3675-4985)
- Chen Liu (ORCID: https://orcid.org/0000-0002-7333-8489)
- Xiaoxiao Zhao (ORCID: https://orcid.org/0000-0002-8006-6418)
- Runzhen Chen (ORCID: https://orcid.org/0000-0003-1139-495X)
- Jinying Zhou (ORCID: https://orcid.org/0000-0001-5597-4329)
- Yu Guang Tan (ORCID: https://orcid.org/0000-0002-8166-0582)
- Li Song (ORCID: https://orcid.org/0000-0003-3502-3803)
- Nan Li (ORCID: https://orcid.org/0000-0002-7529-0781)
- Yi Chen (ORCID: https://orcid.org/0000-0002-7887-0175)
- Jiannan Li (ORCID: https://orcid.org/0000-0001-5981-6731)
- Shaodi Yan
- Hongbing Yan (ORCID: https://orcid.org/0000-0002-8203-2588)
- Hanjun Zhao (ORCID: https://orcid.org/0000-0002-4642-1682)
Institutions
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Fudan University (CN)
- Zhongshan Hospital (CN)
- Fu Wai Hospital (CN)
Publication Details
- Journal
- Genome Medicine
- Published
- 2025-08-25
- DOI
- https://doi.org/10.1186/s13073-025-01531-8
- Primary Topic
- Cardiac tumors and thrombi
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Chinese Academy of Medical Sciences