Trifluoroborate-appended cyclen complexes of paramagnetic transition metals (Ni<sup>2+</sup>, Co<sup>2+</sup>) as fast-relaxing <sup>19</sup>F MRI probes
For the first time, trifluoroborate groups (BF<sub>3</sub>) have been investigated as sensitive probes for <sup>19</sup>F Magnetic Resonance Imaging (MRI) in paramagnetic complexes. Using a macrocyclic BF<sub>3</sub>-appended cyclen ligand, complexes of Ni<sup>2+</sup> and Co<sup>2+</sup> cations were synthesized and exhibited very fast <i>T</i><sub>1</sub> and <i>T</i><sub>2</sub> relaxation times that improve <sup>19</sup>F MRI detection. Notably, the cobalt complex presents the fastest <sup>19</sup>F MRI relaxation reported to date for a Co<sup>2+</sup>-based probe.
Authors
- Noémie Lalaoui (ORCID: https://orcid.org/0000-0002-1313-2876)
- Raphaël Tripier
- Nathalie Saffon‐Merceron (ORCID: https://orcid.org/0000-0002-0301-4163)
- Thibault Troadec (ORCID: https://orcid.org/0000-0002-8005-4302)
- Charline Sire (ORCID: https://orcid.org/0009-0008-8693-0423)
- Francesca Garello (ORCID: https://orcid.org/0000-0002-7150-2003)
- Lorenzo Tei (ORCID: https://orcid.org/0000-0002-7027-8396)
- Nicolas Le Poul (ORCID: https://orcid.org/0000-0002-5915-3760)
Institutions
- Università degli Studi del Piemonte Orientale “Amedeo Avogadro” (IT)
- Centre National de la Recherche Scientifique (FR)
- Université de Bretagne Occidentale (FR)
- Université Fédérale de Toulouse Midi-Pyrénées (FR)
- Toulouse Mathematics Institute (FR)
- Laboratoire Chimie Electrochimie Moléculaires et Chimie Analytique (FR)
- Laboratoire des Sciences et Techniques de l’Information de la Communication et de la Connaissance (FR)
- University of Turin (IT)
Publication Details
- Journal
- Dalton Transactions
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1039/d5dt01834j
- Primary Topic
- Lanthanide and Transition Metal Complexes
- Type
- article
- Field-Weighted Citation Impact
- 0.00