Surgery of Xen45 Gel Micro-Implant and Phacoemulsification: Cross-Sectional Research

Objective: To investigate the safety and effectiveness of XEN45 gel micro-implant and phacoemulsification combined surgery in primary open-angle glaucoma (POAG) patients. Material and Methods: It is a prospective, single-center, clinical study. 30 patients (30 eyes) who were followed up by Marmara University Glaucoma outpatient clinic due to POAG and cataract were included in the study. Moreover, all patients underwent XEN45 gel micro-implant- phacoemulsification combined surgery. Best corrected visual acuity, slit-lamb biomicroscopic examination, intraocular pressure measurement with applanation, Retinal Nerve Fiber Layer and Ganglion Cell Complex scanning were followed up to the 1st post-operative year. Results: Of the participants diagnosed with POAG and cataract, 50% were female, 50% were male, and the average age was 62.63±7.05. A statistically significant decrease was detected in the number of pre-operative antiglaucomatous molecules used by the patients (3.24±0.95) at the end of 1 year (0.66±0.72) (p=0.001). A significant difference was detected between pre and post-operative month 12 intraocular pressure values (22.53±3.81, 14.53±2.86 mmHg, respectively) (p<0.001). At the end of 1 year, the full success rate was 40% and the partial success rate was 36.67%. Conclusion: It was concluded that in addition to being a micro-invasive, effective and reliable surgery, the XEN45 gel micro-implant has been observed to reduce POAG progression and the use of anti-glaucomatous drops.