ASSESSMENT OF OSTEOPOROSIS IN TYPE 2 DIABETES PATIENTS BY OSTA AND FRAX

Objective: We investigated the accuracy of OSTA and FRAX screening tools (without BMD measurements) in identifying osteoporosis among Type 2 diabetes patients. Methodology: This study was performed at the Department of Diabetes and Endocrinology, Lady Reading Hospital Peshawar, and included 174 T2DM patients aged 45-65 of either sex who had “Dual-Energy X-ray absorptiometry” (DEXA) scan. Results: Osteoporosis was detected in 28.6% of lumbar spine measurements and 22.3% of femoral neck measurements. Researchers identified a strong negative correlation between bone mineral density (BMD) and FRAX score for both “Major Osteoporotic Fractures” (MOF) and “Hip Fractures” (HF) at both skeletal sites examined (p < 0.001). The OSTA score demonstrated a positive correlation with BMD at both the lumbar spine (p = 0.002) and femoral neck (p < 0.001). When assessing predictive performance, area under the curve (AUC) values were 0.83 (95% CI, 0.7-0.9) for FRAX-MOF, 0.87 (95% CI, 0.8-0.9) for FRAX-HF, and 0.61 (95% CI, 0.5-0.7) for OSTA. Conclusion: Both OSTA and FRAX effectively detect primary osteoporosis, with FRAX showing slightly superior performance in type 2 diabetes patients. These tools help identify high-risk T2DM patients and provide practical solutions for appropriately using DEXA scans, especially in areas without DEXA availability