Ionic-liquid mediated one-pot synthesis of novel thiazolidinones containing pyrazole and thiazole hybrid as COX-1/COX-2 inhibitor

A one-pot, ionic-liquid mediated synthesis has been developed for novel thiazolidine-4-ones containing a pyrazole and thiazole hybrid.This was achieved using a three-component reaction of 2-aminothiazole, pyrazole-3-aldehyde, and mercaptoacetic acid in [bmim][PF6].The whole procedure is robust and straightforward.By employing this protocol, a series of novel thiazolidine-4-ones containing pyrazole and thiazole hybrids were prepared in good yield (56-88%) and their preliminary cyclooxygenase activities were also studied and reported.The compounds 3h and 3k show the top-tier selective index for cyclooxygenase enzyme, in comparable with celecoxib as a standard.