Targeting Ferroptosis With Ginsenoside Rg3 Alleviates Intervertebral Disc Degeneration
This study elucidates the therapeutic mechanism of Rg3 in delaying IVDD progression via PRKAA2-mediated ferroptosis inhibition, providing substantial experimental evidence for its clinical translation as a potential disease-modifying agent.
Authors
- Yinhuan Wang
- Fei Geng
- Kaihui Zhang (ORCID: https://orcid.org/0000-0003-4799-9133)
- Wenhu Xu (ORCID: https://orcid.org/0009-0009-3716-0941)
Institutions
- North China University of Science and Technology (CN)
- Tianjin University (CN)
- Tianjin Hospital (CN)
Publication Details
- Journal
- Orthopaedic Surgery
- Published
- 2025-08-25
- DOI
- https://doi.org/10.1111/os.70150
- Primary Topic
- Spine and Intervertebral Disc Pathology
- Type
- article
- Field-Weighted Citation Impact
- 0.00