Overexpression of the human heat shock protein B1 alters obesity-related metabolic changes in a sex-dependent manner in a mouse model of metabolic syndrome
Both sexes of APOB animals developed MetS. APOB males presented LVH with preserved ejection fraction (EF); however, APOB females showed enlarged left ventricular end-systolic volume (LVESV). In APOB animals, HSPB1 overexpression exerted a sex-dependent influence on obesity-related alterations, including weight gain, hypercholesterolemia, and hepatic and vWAT gene expression.
Authors
- András Kriston (ORCID: https://orcid.org/0000-0001-8500-4315)
- Petra Hajdu
- Zsófia Ruppert
- Ákos Hunya (ORCID: https://orcid.org/0000-0002-4547-9284)
- Gergő Szűcs (ORCID: https://orcid.org/0000-0003-1874-2718)
- Brigitta Dukay
- Márta Sárközy (ORCID: https://orcid.org/0000-0002-5929-2146)
- Miklós Sántha (ORCID: https://orcid.org/0000-0001-5176-6143)
- László Vı́gh (ORCID: https://orcid.org/0000-0001-7450-105X)
- Péter Monostori (ORCID: https://orcid.org/0000-0003-3591-6054)
- Tamás Csont (ORCID: https://orcid.org/0000-0001-5792-2768)
- Zsolt Galla (ORCID: https://orcid.org/0000-0002-9166-1212)
- Melinda Tóth (ORCID: https://orcid.org/0000-0001-6300-7945)
- Zsolt Török (ORCID: https://orcid.org/0000-0003-0836-3247)
- Péter Horváth (ORCID: https://orcid.org/0000-0002-4492-1798)
- László Tiszlavicz (ORCID: https://orcid.org/0000-0003-1134-6587)
- Bettina Rákóczi
- Gábor Cserni
- Ferenc Kovács (ORCID: https://orcid.org/0000-0003-4512-4448)
Institutions
- University of Szeged (HU)
- HUN-REN Szegedi Biológiai Kutatóközpont (HU)
- Helmholtz Zentrum München (DE)
- Institute of Biochemistry (HU)
Publication Details
- Journal
- Biology of Sex Differences
- Published
- 2025-08-25
- DOI
- https://doi.org/10.1186/s13293-025-00746-z
- Primary Topic
- Heat shock proteins research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Magyar Tudományos Akadémia
- Emberi Eroforrások Minisztériuma
- Nemzeti Kutatási Fejlesztési és Innovációs Hivatal
- Szegedi Tudományegyetem
- National Research, Development and Innovation Office