Study of Synthesis and Antimicrobial Activity of Cynuricchloride Based 1,2,4-Triazoles

The study of heterocyclic systems is of great interest both from the theoretical and practical point of view. Heterocyclic chemistry is an integral part of the chemical sciences and constitutes a considerable part of the modern researches. Triazole is 5-membered heterocycle containing three nitrogen atoms present at 1,2 and 4th position of the ring. It can be viewed as a derivative of cyanuricchloride based heterocycles. Compounds containing this functional group are useful commercially in analgesics and dyes. In the presence study we have synthesized various 1,2,4-triazoles from novel chalcones upon condensation reaction with 4H-1,2,4-trizoles-3-amine in the presence of NaOH as the base under ethanol solvent. All synthesized compounds were tested for their antimicrobial activity against gram positive and gram-negative bacteria. All the synthesized compounds were characterized by 1HNMR, 13CNMR, IR, MASS spectroscopic techniques.