Dose-dependent modulation of hepatic cytochrome P450 enzymes by tenvermectin: implications for medication safety and combination therapy
As the first study to report the effects of TVM on CYP enzyme activity, these findings provide important experimental evidence and a theoretical framework for its clinical safety assessment, development of optimal dosing regimens, and rational polypharmacy strategies.
Authors
- Can Cui (ORCID: https://orcid.org/0000-0003-1139-0182)
- Wei Ren (ORCID: https://orcid.org/0000-0002-6537-6039)
- Jianping Liang (ORCID: https://orcid.org/0000-0002-2733-2860)
- Xi Huang (ORCID: https://orcid.org/0000-0002-4829-8390)
- Lin Li (ORCID: https://orcid.org/0000-0002-8014-8296)
- Xiangmei Li (ORCID: https://orcid.org/0000-0002-3871-8566)
- Li Lv
Institutions
- South China Agricultural University (CN)
Publication Details
- Journal
- Frontiers in Veterinary Science
- Published
- 2025-08-25
- DOI
- https://doi.org/10.3389/fvets.2025.1647697
- Primary Topic
- Pharmacological Effects and Toxicity Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Key Research and Development Program of China