Identification of potential drug targets and possible drugs for esophageal carcinoma from genetic insights: a comprehensive two-sample Mendelian randomization study
We identified five drug targets by MR analysis and co-localization analysis and four drugs by drug prediction and molecular docking analysis respectively, which provide new insights for treatment of esophageal carcinoma.
Authors
- Aoqing Ye
- Ji Sun (ORCID: https://orcid.org/0000-0002-9302-3177)
- Haibin Ou (ORCID: https://orcid.org/0000-0003-3208-3632)
- Qiuji Wu (ORCID: https://orcid.org/0000-0002-4655-3108)
- Juan Wang (ORCID: https://orcid.org/0000-0003-1992-0539)
- Yu Liu (ORCID: https://orcid.org/0009-0000-6366-2288)
- Liang Chen (ORCID: https://orcid.org/0000-0001-8339-8592)
- Jiong Liu (ORCID: https://orcid.org/0009-0001-2208-2882)
Institutions
- Sun Yat-sen University (CN)
- Wuhan University (CN)
- Zhongnan Hospital of Wuhan University (CN)
- The First Affiliated Hospital, Sun Yat-sen University (CN)
Publication Details
- Journal
- Discover Oncology
- Published
- 2025-08-25
- DOI
- https://doi.org/10.1007/s12672-025-02777-9
- Primary Topic
- Esophageal Cancer Research and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Wuhan University
- Zhongnan Hospital of Wuhan University