GLP-2-carrying exosomes alleviate osteoporosis by upregulating miR-378a-3p to inhibit osteoclastic differentiation and NF-κB-MAPK pathway
GLP-2-carrying exosomes showed promise in treating osteoporosis by inhibiting osteoclast differentiation and modulating NF-κB/MAPK pathways via miR-378a-3p regulation. This novel axis presents a promising dual-targeted strategy for osteoporosis treatment, with engineered exosomes offering significant translational potential for bone regenerative therapy.
Authors
- Kefen Wu
- Kan Xu (ORCID: https://orcid.org/0000-0001-8947-1172)
- Yewei Huang (ORCID: https://orcid.org/0000-0002-8805-9351)
- Yi Lu (ORCID: https://orcid.org/0000-0002-9807-8791)
- Yu Hu (ORCID: https://orcid.org/0000-0003-3883-3887)
- Jiping Shen
Institutions
- Zhongshan Hospital (CN)
- Shanghai Eighth People Hospital (CN)
Publication Details
- Journal
- Journal of Orthopaedic Surgery and Research
- Published
- 2025-08-25
- DOI
- https://doi.org/10.1186/s13018-025-06119-x
- Citations
- 1
- Primary Topic
- Bone Metabolism and Diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.81