Carrier-free Nano-Tetrandrine (PURE-T) for Psoriasis Treatment: Significant Therapeutic Efficacy and Its Regulatory Mechanism on Stratum Corneum Inflammation
As an incurable systemic autoimmune disease, psoriasis is in urgent need of safe and effective treatment strategies. As a natural product extracted from Chinese herbs, Tetrandrine (Tet) has a wide range of pharmacological effects. In this study, we developed a carrier-free nano Tet topical formulation (PURE-T) by antisolvent method, and verified that it could selectively attenuate the toxicity of HaCaT cells in the normal state and potentiate the efficacy of HaCaT cells in the inflammatory state in vitro, and in vivo experiments verified that it could normalize the epidermal layer of the skin of imiquimod (IMQ)-induced psoriasis-like mice, and reduce the infiltration of inflammatory cells in the superficial layer of the dermis; mechanistic studies suggested that PURE-T may achieve therapeutic treatment of psoriasis through the GSDMC-mediated noninflammatory pyroptosis pathway. This safe, effective, carrier-free topical nanoformulation has potential for clinical translation and large-scale production.
Authors
- Ziqi Zhuang (ORCID: https://orcid.org/0009-0007-2144-6182)
- Liqian Zhao (ORCID: https://orcid.org/0000-0001-5068-3688)
- Yan You
- Chengchao Chu (ORCID: https://orcid.org/0000-0002-1694-9363)
- Bocheng Yang (ORCID: https://orcid.org/0009-0008-6433-7661)
- Lili Jiang
- Xiaofei Wen (ORCID: https://orcid.org/0000-0003-2216-923X)
- Jinyong Lin (ORCID: https://orcid.org/0000-0001-8228-3339)
- Yating Zheng
- Cheng Yao (ORCID: https://orcid.org/0000-0002-7651-6682)
- Anqi Wang (ORCID: https://orcid.org/0000-0002-3369-1499)
- Gang Liu (ORCID: https://orcid.org/0000-0003-2613-7286)
- Peiyu Wang (ORCID: https://orcid.org/0000-0002-6455-5043)
- Changhong Li (ORCID: https://orcid.org/0009-0006-2213-0481)
- Yi Xue (ORCID: https://orcid.org/0009-0006-8614-1913)
- Liang Zhang (ORCID: https://orcid.org/0000-0003-0782-0688)
- Wei Zhou (ORCID: https://orcid.org/0000-0003-4030-2022)
Institutions
- Mongolian University of Science and Technology (MN)
- Harbin Medical University (CN)
- Quanzhou Normal University (CN)
- Xiamen University (CN)
- Chinese Academy of Sciences (CN)
- Peking University (CN)
- Inner Mongolia University of Science and Technology (CN)
- First Affiliated Hospital of Xiamen University (CN)
- Society of Interventional Radiology (US)
- Children's Hospital of Zhejiang University (CN)
- Laboratoire d’Imagerie Biomédicale (FR)
- Center for Excellence in Molecular Cell Science (CN)
- Fourth Affiliated Hospital of Harbin Medical University (CN)
- Zhongshan Hospital of Xiamen University (CN)
- National Clinical Research (US)
- Taiwan Centers for Disease Control (TW)
- Peking University Third Hospital (CN)
- Shenzhen Institutes of Advanced Technology (CN)
- Zhejiang University (CN)
Publication Details
- Journal
- ACS Applied Materials & Interfaces
- Published
- 2025-08-25
- DOI
- https://doi.org/10.1021/acsami.5c12837
- Citations
- 1
- Primary Topic
- Psoriasis: Treatment and Pathogenesis
- Type
- article
- Field-Weighted Citation Impact
- 0.80
Funders
- National Natural Science Foundation of China
- China Postdoctoral Science Foundation
- Heilongjiang Provincial Science and Technology Department
- Natural Science Foundation of Zhejiang Province