Risk factors for pneumonitis after the combination treatment of immune checkpoint inhibitors and thoracic radiotherapy
We first showed that older, male patients are more likely to suffer from pneumonitis of Grade 2 and above. We also found that, numerically, patients who received ICIs before radiotherapy (RT) were more likely to have pneumonitis than those who received RT before ICIs. Moreover, a longer interval between treatments, lower mean lung dose (MLD) and smaller ipsilateral or bilateral lung dose‒volume parameters are correlated with a lower incidence of pneumonitis of Grade 2 or above.
Authors
- Qichun Wei (ORCID: https://orcid.org/0000-0002-8688-5000)
- Binbin Zheng-Lin (ORCID: https://orcid.org/0000-0002-2478-8299)
- Jing Zhao (ORCID: https://orcid.org/0000-0002-9583-9284)
- Siyu Guo (ORCID: https://orcid.org/0000-0001-6995-0352)
- Ting Zhang (ORCID: https://orcid.org/0000-0002-2044-2610)
- Xia Yang (ORCID: https://orcid.org/0000-0003-0612-7523)
- Yang Tang (ORCID: https://orcid.org/0000-0002-0169-7028)
- Dang Wu (ORCID: https://orcid.org/0000-0002-3202-6470)
- Yanhong Yao (ORCID: https://orcid.org/0000-0003-0499-5554)
- Haifeng Yu (ORCID: https://orcid.org/0009-0007-5407-9497)
Institutions
- Zhejiang Cancer Hospital (CN)
- Ningbo No. 2 Hospital (CN)
- Second Affiliated Hospital of Zhejiang University (CN)
- Ningbo No.6 Hospital (CN)
- University of Chinese Academy of Sciences (CN)
- Ningbo First Hospital (CN)
- Zhejiang University (CN)
Publication Details
- Journal
- BMC Pulmonary Medicine
- Published
- 2025-08-25
- DOI
- https://doi.org/10.1186/s12890-025-03871-y
- Primary Topic
- Cancer Immunotherapy and Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Zhejiang University
- Chinese Society of Clinical Oncology
- Medical Science and Technology Project of Zhejiang Province
- Natural Science Foundation of Zhejiang Province
- Science and Technology Program of Zhejiang Province