In silico evaluation of the potential of very high energy electrons delivered in both conventional and FLASH regimes for the SBRT treatment of pancreatic cancer: A report of three case studies
The obtained results demonstrate the suitability of VHEE for pancreatic cancer treatment with optimized plans that are clinically acceptable even without considering the additional sparing from the FLASH effect. Their suitability for being delivered at FLASH rates makes them an excellent candidate for the future of external beam radiotherapy.
Authors
- D. N. Carlotti (ORCID: https://orcid.org/0000-0003-0495-8876)
- Michele Fiore (ORCID: https://orcid.org/0000-0003-1889-4578)
- Gaia Franciosini (ORCID: https://orcid.org/0000-0001-8088-953X)
- M. Marafini (ORCID: https://orcid.org/0000-0003-1282-0383)
- A. Schiavi (ORCID: https://orcid.org/0000-0002-7081-2747)
- T. Insero
- A. Trigilio (ORCID: https://orcid.org/0000-0001-8752-092X)
- A. Sarti (ORCID: https://orcid.org/0000-0001-5419-7951)
- Angelica De Gregorio
- M. Toppi (ORCID: https://orcid.org/0000-0002-0392-0895)
- S. Ramella
- Annalisa Muscato
- G. Traini (ORCID: https://orcid.org/0000-0001-9234-6321)
- V. Marè
- V. Patera (ORCID: https://orcid.org/0000-0003-1999-8424)
- F Quattrini
- A Burattini
Institutions
- Istituto Nazionale di Fisica Nucleare (IT)
- Centro Ricerche Enrico Fermi (IT)
- Istituto Nazionale di Fisica Nucleare, Laboratori Nazionali di Frascati (IT)
- Campus Bio Medico University Hospital (IT)
- Sapienza University of Rome (IT)
Publication Details
- Journal
- Physica Medica
- Published
- 2025-08-25
- DOI
- https://doi.org/10.1016/j.ejmp.2025.105076
- Primary Topic
- Radiation Therapy and Dosimetry
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- European Commission
- Ministero dell’Istruzione, dell’Università e della Ricerca
- Instituto Nazionale di Fisica Nucleare