Mechanisms in Crossing the Blood-brain Barrier Using PLGA Nanoparticles

Poly(lactic-co-glycolic acid) (PLGA) is a unique nanomaterial and polymer that stands out due to its unique properties. With crossing the BBB for drug delivery, PLGA shows promise. This literature review aims to examine the current research on the promising use of PLGA nanoparticles and their use of crossing the BBB. Crossing the BBB has remained a roadblock in drug delivery for a long time, and crossing this barrier would revolutionize drug delivery and would significantly benefit the medical community. This review will dive deep into the properties of PLGA nanoparticles, methods of drug delivery through the use of PLGA nanoparticles, and how these PLGA nanoparticles can efficiently and safely cross the BBB. Additionally, this review will highlight many studies showing the potential and effectiveness of PLGA nanoparticles in drug-delivery systems in the brain. Effectively crossing the BBB for drug delivery in the brain can change how doctors treat many neurological diseases and change the field of medicine and a future run by nanotechnology and nanomedicine. By utilizing current strategies in using PLGA nanoparticles in crossing the BBB, this review also aims to make PLGA one of the more critical nanoparticles for research in the future of nanomedicine.