Gene Mutation Analysis in Colorectal Cancer: Identification of Critical Genetic Drivers and Their Role in Tumor Development

Colorectal cancer (CRC) remains one of the leading causes of cancer-related mortality worldwide, with complex genetic factors contributing to its development. This study focuses on analyzing specific gene mutations associated with colorectal cancer to identify key genetic drivers that influence tumorigenesis. By utilizing high-throughput sequencing data and bioinformatics approaches, we aim to detect recurrent mutations in oncogenes, tumor suppressor genes, and regulatory elements implicated in CRC. Through correlation studies between identified genetic alterations and tumor characteristics, this research seeks to clarify the functional role of these mutations in promoting colorectal tumor progression. The findings could contribute to precision medicine approaches, offering insights for potential targeted therapies and improved diagnostic methods in colorectal cancer.

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Publication Details

Journal
Journal of Student Research
Published
2025-02-28
DOI
https://doi.org/10.47611/jsrhs.v14i1.8987
Primary Topic
Cancer Genomics and Diagnostics
Type
article
Field-Weighted Citation Impact
0.00
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article

Gene Mutation Analysis in Colorectal Cancer: Identification of Critical Genetic Drivers and Their Role in Tumor Development

Arthi Vijayaraghavan, Jothsna Kethar, Virgel Torremocha, Prahlad Parajuli
Journal of Student Research
Cancer Genomics and Diagnostics
article

Gene Mutation Analysis in Colorectal Cancer: Identification of Critical Genetic Drivers and Their Role in Tumor Development

Arthi Vijayaraghavan, Jothsna Kethar, Virgel Torremocha, Prahlad Parajuli
article en

Abstract

Colorectal cancer (CRC) remains one of the leading causes of cancer-related mortality worldwide, with complex genetic factors contributing to its development. This study focuses on analyzing specific gene mutations associated with colorectal cancer to identify key genetic drivers that influence tumorigenesis. By utilizing high-throughput sequencing data and bioinformatics approaches, we aim to detect recurrent mutations in oncogenes, tumor suppressor genes, and regulatory elements implicated in CRC. Through correlation studies between identified genetic alterations and tumor characteristics, this research seeks to clarify the functional role of these mutations in promoting colorectal tumor progression. The findings could contribute to precision medicine approaches, offering insights for potential targeted therapies and improved diagnostic methods in colorectal cancer.

Journal of Student ResearchVol. 14(1)
Wayne State University (US), University of Southeastern Philippines (PH)
Openalex Percentile: Top 72%
Cancer Genomics and Diagnostics
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Gene Mutation Analysis in Colorectal Cancer: Identification of Critical Genetic Drivers and Their Role in Tumor Development — Arthi Vijayaraghavan, Jothsna Kethar, et al. · Journal of Student Research (2025) | TGRS Research Map | TGRS