Ablation of hypothalamic Cnr1 leads to reduced meniscal mineral volume and articular cartilage damage in aging male mice
These results suggest that a lack of hypothalamic CB1 tone reduced circulating levesl of corticosterone, while increasing local meniscal sympathetic tone, which is associated with impaired ATF4 nuclear localization and meniscal mineralization. These events subsequently hinder OA development with age.
Authors
- Eli Farhat
- András Bilkei‐Gorzó (ORCID: https://orcid.org/0000-0002-6805-0472)
- Beat Lutz (ORCID: https://orcid.org/0000-0002-1062-6889)
- Carmen Ruiz de Almodóvar (ORCID: https://orcid.org/0000-0001-5975-7815)
- Mona Dvir‐Ginzberg (ORCID: https://orcid.org/0000-0003-3089-6875)
- Eli Reich
- Michela Palmisano (ORCID: https://orcid.org/0000-0002-6091-7385)
- Carla Florencia Ramunno
- Oriya From
- Miya Marco
Institutions
- University of Bonn (DE)
- Hebrew University of Jerusalem (IL)
- Johannes Gutenberg University Mainz (DE)
- University Medical Center of the Johannes Gutenberg University Mainz (DE)
Publication Details
- Journal
- Osteoarthritis and Cartilage
- Published
- 2025-08-25
- DOI
- https://doi.org/10.1016/j.joca.2025.08.006
- Primary Topic
- Biochemical effects in animals
- Type
- article
- Field-Weighted Citation Impact
- 0.00