Traumatic Brain Injury and Risk of Malignant Brain Tumors in Civilian Populations
In this cohort study of US adult civilians, a history of moderate to severe TBI was associated with risk of developing malignant brain tumors. This association was confirmed in a meta-analysis with geographically diverse sites across the US. Additional research is needed to clarify the mechanism through which TBI increases the risk of developing brain tumors.
Authors
- Joshua D. Bernstock (ORCID: https://orcid.org/0000-0002-7814-3867)
- Ross Zafonte (ORCID: https://orcid.org/0000-0002-1050-796X)
- Jakob V. E. Gerstl (ORCID: https://orcid.org/0000-0002-8100-0517)
- Hunter Mills
- Cathra Halabi (ORCID: https://orcid.org/0000-0002-0331-8183)
- Stephen T. Magill (ORCID: https://orcid.org/0000-0002-5257-7835)
- Ahmad Mashlah
- Anthony M. DiGiorgio (ORCID: https://orcid.org/0000-0002-5710-691X)
- Rachel Grashow (ORCID: https://orcid.org/0000-0001-6961-0243)
- E. Antonio Chiocca
- Sandro Marini (ORCID: https://orcid.org/0000-0001-9101-6996)
- Saef Izzy (ORCID: https://orcid.org/0000-0002-2822-6736)
- Amr Alwakeal (ORCID: https://orcid.org/0000-0001-5440-3874)
- Sharat Israni
- Farid Radmanesh (ORCID: https://orcid.org/0000-0001-5431-0176)
- Gundolf Schenk
- Geoffrey T. Manley
- Muhammad T. Hassan (ORCID: https://orcid.org/0009-0008-0560-6710)
Institutions
- Brigham and Women's Hospital (US)
- Harvard University (US)
- University of California, San Francisco (US)
- Neurosciences Institute (US)
- Spaulding Rehabilitation Hospital (US)
- Massachusetts Mental Health Center (US)
- Northwestern Memorial Hospital (US)
- Neurological Surgery (US)
- The University of Texas Health Science Center (US)
- University of Missouri (US)
Publication Details
- Journal
- JAMA Network Open
- Published
- 2025-08-25
- DOI
- https://doi.org/10.1001/jamanetworkopen.2025.28850
- Citations
- 3
- Primary Topic
- Traumatic Brain Injury and Neurovascular Disturbances
- Type
- article
- Field-Weighted Citation Impact
- 4.17
Funders
- U.S. Department of Defense
- Alliance for Cancer Gene Therapy
- Abbott Laboratories
- Massachusetts General Hospital
- Harvard University
- Charles Koch Foundation
- Strong
- National Football League Players Association
- National Institutes of Health
- National Institute on Deafness and Other Communication Disorders
- National Institute on Disability, Independent Living, and Rehabilitation Research