Integrating multi-modal transcriptomics identifies cellular subtypes with distinct roles in PDAC progression
We delineate two opposing cellular programs in the PDAC TME-tumor-promoting stromal remodeling and anti-tumor immune activation-spatially organized in distinct niches. Those findings suggest that targeting POSTN⁺ fibroblasts and SPP1⁺ macrophages-mediated stromal interactions while promoting CCL4⁺ T cell and IGHG1⁺ plasma cell immunity, may offer new therapeutic strategies for PDAC.
Authors
- Ziyue Li (ORCID: https://orcid.org/0000-0003-4983-9352)
- Qizhou Lian (ORCID: https://orcid.org/0000-0001-8189-7160)
- Meng Pan (ORCID: https://orcid.org/0000-0002-8723-4824)
- Hao Chen (ORCID: https://orcid.org/0000-0001-7654-5910)
- Jierong Chen
- Guansheng Zheng
- Wu Jun (ORCID: https://orcid.org/0000-0002-1717-0378)
- Wei Zhang (ORCID: https://orcid.org/0009-0002-3801-5729)
- Tenghui Dai
- Yang Liu (ORCID: https://orcid.org/0009-0003-1034-3277)
- Qiao Li (ORCID: https://orcid.org/0000-0002-8826-710X)
Institutions
- Wannan Medical College (CN)
- Sun Yat-sen University (CN)
- Hunan University (CN)
- South China Normal University (CN)
- Nanfang Hospital (CN)
- Guangzhou Women and Children Medical Center (CN)
- Guangdong Academy of Medical Sciences (CN)
- Sun Yat-sen University Cancer Center (CN)
- Southern Medical University (CN)
- Guangzhou Medical University (CN)
Publication Details
- Journal
- Cellular Oncology
- Published
- 2025-08-25
- DOI
- https://doi.org/10.1007/s13402-025-01100-6
- Citations
- 2
- Primary Topic
- Immune cells in cancer
- Type
- article
- Field-Weighted Citation Impact
- 1.59
Funders
- National Natural Science Foundation of China