Comparison of capillary dried blood spot and capillary microtubes with venous immunoglobulin G levels for routine diagnostics
IgG measurements from DBS demonstrated insufficient correlation and excessively broad limits of agreement, making it unsuitable for accurately determining IgG levels. This result hampers implementation of DBS in routine diagnostics. Conversely, capillary microtube samples demonstrated a strong correlation and narrow limits of agreement, which makes them a viable alternative to venipuncture.
Authors
- Joris M. van Montfrans (ORCID: https://orcid.org/0000-0001-6764-0211)
- Martijn J. H. Doeleman (ORCID: https://orcid.org/0000-0003-4786-4108)
- Wouter M. Tiel Groenestege (ORCID: https://orcid.org/0000-0001-6382-7361)
- D. Hamann
- Leosa R. Soels
- Sharisa L. Boland
- Sytze de Roock (ORCID: https://orcid.org/0009-0003-7281-1304)
- T. Visser
- Lotte Hofstee
Institutions
- Utrecht University (NL)
- University Medical Center Utrecht (NL)
Publication Details
- Journal
- Clinical Biochemistry
- Published
- 2025-08-25
- DOI
- https://doi.org/10.1016/j.clinbiochem.2025.110996
- Citations
- 1
- Primary Topic
- Immunodeficiency and Autoimmune Disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.80
Funders
- Siemens Medical Solutions USA