Damnacanthus giganteus extract block diffuse large b-cell lymphoma proliferation and EMT by regulating mitochondrial dysfunction and glycolysis

‌Our study demonstrates for the first time that DGE effectively suppresses tumor proliferation and EMT during DLBCL progression. These antitumor effects appear to be mediated through modulation of mitochondrial function and glycolysis. These findings position DGE as a promising novel therapeutic candidate for DLBCL treatment, meriting immediate clinical translation and further evaluation.

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Publication Details

Journal
Hereditas
Published
2025-08-25
DOI
https://doi.org/10.1186/s41065-025-00531-3
Primary Topic
Histone Deacetylase Inhibitors Research
Type
article
Field-Weighted Citation Impact
0.00
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article

Damnacanthus giganteus extract block diffuse large b-cell lymphoma proliferation and EMT by regulating mitochondrial dysfunction and glycolysis

SuLing Chen, Jiangcun Wei, Xiao Ma, Zhiqiang Qin et al.
Hereditas
Histone Deacetylase Inhibitors Research
article

Damnacanthus giganteus extract block diffuse large b-cell lymphoma proliferation and EMT by regulating mitochondrial dysfunction and glycolysis

SuLing Chen, Jiangcun Wei, Xiao Ma, Zhiqiang Qin, Peng Yang, Guangying Zhou, Manjing Huang, Bing Qing
article en

Abstract

‌Our study demonstrates for the first time that DGE effectively suppresses tumor proliferation and EMT during DLBCL progression. These antitumor effects appear to be mediated through modulation of mitochondrial function and glycolysis. These findings position DGE as a promising novel therapeutic candidate for DLBCL treatment, meriting immediate clinical translation and further evaluation.

HereditasVol. 162(1)
Guangxi University (CN), Guangxi Zhuang Autonomous Region Health and Family Planning (CN), Guangxi University of Chinese Medicine (CN), The People's Hospital of Guangxi Zhuang Autonomous Region (CN), Riverside Hospital of Guangxi Zhuang Autonomous Region (CN)
Openalex Percentile: Top 80%
Histone Deacetylase Inhibitors Research
DOIOpen Access PDFOpenAlex
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Damnacanthus giganteus extract block diffuse large b-cell lymphoma proliferation and EMT by regulating mitochondrial dysfunction and glycolysis — SuLing Chen, Jiangcun Wei, et al. · Hereditas (2025) | TGRS Research Map | TGRS