Choroid Plexus Enlargement in Multiple Sclerosis Correlates with Cortical and Phase Rim Lesions on 7T MRI and Predicts Progression Independent of Relapse Activity
In MS, a CPR increase relates to imaging markers of compartmentalized disease activity including cortical lesions and PRLs and is a critical predictor of disease progression. Our findings could provide the rationale for implementing CPR estimation for prognosis prediction in MS.
Authors
- Alessandro Miscioscia (ORCID: https://orcid.org/0000-0001-7465-6246)
- Nicola Toschi (ORCID: https://orcid.org/0000-0003-1929-5833)
- Valeria Barletta (ORCID: https://orcid.org/0000-0003-0655-9406)
- Caterina Mainero (ORCID: https://orcid.org/0000-0003-3244-8507)
- Elena Barbuti (ORCID: https://orcid.org/0000-0002-0450-7699)
- Allegra Conti (ORCID: https://orcid.org/0000-0003-4210-5065)
- Eric C. Klawiter (ORCID: https://orcid.org/0000-0002-3429-2633)
- Jacob A. Sloane (ORCID: https://orcid.org/0000-0003-0028-3031)
- Elena Herranz (ORCID: https://orcid.org/0000-0001-7207-6811)
- Constantina A. Treaba (ORCID: https://orcid.org/0000-0001-8260-207X)
Institutions
- University of Rome Tor Vergata (IT)
- Beth Israel Deaconess Medical Center (US)
- Harvard University (US)
- Beth Israel Deaconess Hospital (US)
- Massachusetts General Hospital (US)
- Athinoula A. Martinos Center for Biomedical Imaging (US)
- Sapienza University of Rome (IT)
Publication Details
- Journal
- American Journal of Neuroradiology
- Published
- 2025-08-25
- DOI
- https://doi.org/10.3174/ajnr.a8983
- Citations
- 1
- Primary Topic
- Multiple Sclerosis Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 1.47