Calcitonin Gene-Related Peptide Ameliorates Experimental Dry Eye Disease
Our data demonstrate that CGRP expression in the cornea and TG is downregulated in DED. Topical CGRP treatment ameliorates DED severity by promoting epithelial proliferation and suppressing inflammation in the cornea.
Authors
- Asmaa A. Zidan (ORCID: https://orcid.org/0000-0001-8248-8190)
- Sheyda Najafi (ORCID: https://orcid.org/0000-0001-9334-6374)
- Elsayed Elbasiony
- Bhupender Verma (ORCID: https://orcid.org/0000-0002-5280-2836)
- Zhirong Lin (ORCID: https://orcid.org/0009-0004-7063-1438)
- Jia Yin (ORCID: https://orcid.org/0000-0003-1340-6758)
- Shuyan Zhu
- Amirreza Naderi
Institutions
- Massachusetts Eye and Ear Infirmary (US)
- Xiamen University (CN)
- Yale University (US)
- Pulmonary Hospital of Lanzhou (CN)
- He Eye Hospital (CN)
- Smith-Kettlewell Eye Research Institute (US)
Publication Details
- Journal
- Investigative Ophthalmology & Visual Science
- Published
- 2025-08-25
- DOI
- https://doi.org/10.1167/iovs.66.11.58
- Citations
- 1
- Primary Topic
- Ocular Surface and Contact Lens
- Type
- article
- Field-Weighted Citation Impact
- 1.88
Funders
- U.S. Department of Defense
- Research to Prevent Blindness
- Massachusetts Lions Eye Research Fund
- Congressionally Directed Medical Research Programs