Investigating genetic, antigenic, and structural diversity in the <i>Neisseria gonorrhoeae</i> outer membrane protein, PorB: implications for vaccine design

In the context of rising global gonorrhea cases, the development of vaccines becomes a priority; however, <i>N. gonorrhoeae</i> antigenic diversity and its ability to evade the immune system complicate vaccine development. This study characterizes the genetic diversity of the outer membrane protein, PorB, a key component of the outer membrane and a major gonococcal antigen. Using genomics and machine-learning techniques, this research identified dominant PorB variants that drive the immune response, proposing potential vaccine candidates and improving our understanding of the evolutionary forces maintaining genome structure and biological fitness. Understanding these processes is crucial for designing vaccines that effectively target <i>N. gonorrhoeae</i> and combat the spread of multidrug-resistant gonococci.

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Publication Details

Journal
mBio
Published
2025-08-25
DOI
https://doi.org/10.1128/mbio.01309-25
Citations
1
Primary Topic
Bacterial Infections and Vaccines
Type
article
Field-Weighted Citation Impact
1.18

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article

Investigating genetic, antigenic, and structural diversity in the Neisseria gonorrhoeae outer membrane protein, PorB: implications for vaccine design

Margaret C. Bash, Ann E. Jerse, Rebekah A. Jones, Lenka Stejskal et al.
1 citations
mBio
Bacterial Infections and Vaccines
1.18
article

Investigating genetic, antigenic, and structural diversity in the Neisseria gonorrhoeae outer membrane protein, PorB: implications for vaccine design

Margaret C. Bash, Ann E. Jerse, Rebekah A. Jones, Lenka Stejskal, Angela Thistlethwaite, Ian M. Feavers, Odile B. Harrison, Eduard J. Sanders, Christoph M. Tang, Jeremy P. Derrick, Fidel Ramírez Bencomo, Martin Maiden
article en
1 citations

Abstract

In the context of rising global gonorrhea cases, the development of vaccines becomes a priority; however, <i>N. gonorrhoeae</i> antigenic diversity and its ability to evade the immune system complicate vaccine development. This study characterizes the genetic diversity of the outer membrane protein, PorB, a key component of the outer membrane and a major gonococcal antigen. Using genomics and machine-learning techniques, this research identified dominant PorB variants that drive the immune response, proposing potential vaccine candidates and improving our understanding of the evolutionary forces maintaining genome structure and biological fitness. Understanding these processes is crucial for designing vaccines that effectively target <i>N. gonorrhoeae</i> and combat the spread of multidrug-resistant gonococci.

mBioVol. 16(10)
Unifor (NO), United States Food and Drug Administration (US), Uniformed Services University of the Health Sciences (US), University of Oxford (GB), Aurum Institute (ZA), Food and Drug Administration (TH), Centre for Inflammation Research (GB)
Wellcome Trust
Openalex Percentile: Top 18%
Bacterial Infections and Vaccines
1.18
DOIOpen Access PDFOpenAlex
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