Human fecal microbiota transplantation attenuates high dietary oxalate-induced renal calcium oxalate crystal depositions in rats via repairing <i>Allobaculum-</i> related gut barrier damage

This study investigated that healthy hFMT could serve as a novel strategy to inhibit kidney CaOx deposition induced by HDOx diet. By transplanting healthy human gut microbiota into HDOx rats, we found that hFMT significantly reduced CaOx crystal depositions and kidney damage. The treatment also restored the gut microbiota composition, particularly the abundance of <i>Allobaculum</i>, a genus closely associated with CaOx crystal depositions. Importantly, hFMT restored intestinal barrier function, providing a new mechanistic insight into the gut-kidney axis in kidney stone formation. These findings highlight hFMT's potential as a therapeutic strategy for managing hyperoxaluria and kidney stone, offering a promising alternative to traditional treatment.

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Publication Details

Journal
mSystems
Published
2025-08-25
DOI
https://doi.org/10.1128/msystems.00810-25
Primary Topic
Kidney Stones and Urolithiasis Treatments
Type
article
Field-Weighted Citation Impact
0.00

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article

Human fecal microbiota transplantation attenuates high dietary oxalate-induced renal calcium oxalate crystal depositions in rats via repairing Allobaculum- related gut barrier damage

Mingzhao Zhu, Jie Gao, Shujue Li, Zhenglin Chang et al.
mSystems
Kidney Stones and Urolithiasis Treatments
article

Human fecal microbiota transplantation attenuates high dietary oxalate-induced renal calcium oxalate crystal depositions in rats via repairing Allobaculum- related gut barrier damage

Mingzhao Zhu, Jie Gao, Shujue Li, Zhenglin Chang, Lingyue An, Xiaolu Duan, Min Lei, Wenwen Cai, Wenqi Wu, Yuhao Zhou, Shike Zhang, Renjie Jiao, Yangzhi Xu, Daqiang Wei, Hui Yang, Yīmíng Bào
article en

Abstract

This study investigated that healthy hFMT could serve as a novel strategy to inhibit kidney CaOx deposition induced by HDOx diet. By transplanting healthy human gut microbiota into HDOx rats, we found that hFMT significantly reduced CaOx crystal depositions and kidney damage. The treatment also restored the gut microbiota composition, particularly the abundance of <i>Allobaculum</i>, a genus closely associated with CaOx crystal depositions. Importantly, hFMT restored intestinal barrier function, providing a new mechanistic insight into the gut-kidney axis in kidney stone formation. These findings highlight hFMT's potential as a therapeutic strategy for managing hyperoxaluria and kidney stone, offering a promising alternative to traditional treatment.

mSystemsVol. 10(9)
Chinese Academy of Sciences (CN), Second Affiliated Hospital of Guangzhou Medical University (CN), First Affiliated Hospital of Guangzhou Medical University (CN), Institute of Biophysics (CN), Czech Academy of Sciences, Institute of Microbiology (CZ), Institute of Microbiology (CN), Guangzhou Medical University (CN)
National Natural Science Foundation of China, Natural Science Foundation of Guangdong Province
Openalex Percentile: Top 67%
Kidney Stones and Urolithiasis Treatments
DOIOpen Access PDFOpenAlex
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