Effects of simultaneous administration of local anesthetics on seizure induced threshold: an experimental study in rats
This study revealed no clear evidence of antagonism or synergism for the simultaneous administration of short-acting (lidocaine or mepivacaine) and long-acting anesthetics (ropivacaine or levobupivacaine). An additive effect was suggested in terms of the seizure threshold when short- and long-acting local anesthetics were administered simultaneously. This finding may therefore support the safe and effective combined use of local anesthetics in clinical regional anesthesia.
Authors
- Atsuyuki Hosono (ORCID: https://orcid.org/0000-0002-8523-648X)
- Satoki Inoue (ORCID: https://orcid.org/0000-0001-8746-3152)
- Shinju Obara (ORCID: https://orcid.org/0000-0001-8619-2864)
- Masahiro Murakawa (ORCID: https://orcid.org/0000-0003-0196-1914)
- Yoshie Noji (ORCID: https://orcid.org/0000-0002-4638-7701)
- Keisuke Yoshida (ORCID: https://orcid.org/0000-0003-1086-6054)
Institutions
- Fukushima Medical University (JP)
- Miwa Hospital (JP)
Publication Details
- Journal
- BMC Anesthesiology
- Published
- 2025-08-25
- DOI
- https://doi.org/10.1186/s12871-025-03305-6
- Citations
- 2
- Primary Topic
- Anesthesia and Pain Management
- Type
- article
- Field-Weighted Citation Impact
- 4.01
Funders
- Japan Society for the Promotion of Science