Molecular profiles of the great obstetrical syndromes reveal common features and dynamic changes in early pregnancy
We highlight the shared molecular signatures among different GOS conditions in the pre-symptomatic phase, suggesting the potential of a common screening and intervention strategy. Our results further support the notion that the prevention of GOS should start at 14 weeks of gestation or earlier, when the molecular signature changes have already emerged.
Authors
- Xiaojing Zeng (ORCID: https://orcid.org/0000-0001-8564-3539)
- Xipeng Wang (ORCID: https://orcid.org/0000-0001-8393-3719)
- Qianlong Zhang (ORCID: https://orcid.org/0000-0002-8073-9467)
- Lisong Shen (ORCID: https://orcid.org/0000-0002-6647-4749)
- Lin Zhang (ORCID: https://orcid.org/0000-0002-7404-5231)
- Jun Zhang (ORCID: https://orcid.org/0000-0003-1706-1611)
- Kun Sun (ORCID: https://orcid.org/0000-0002-0504-7372)
- Jian Zhao (ORCID: https://orcid.org/0000-0002-8862-0591)
- Yuexin Gan
Institutions
- Shanghai Jiao Tong University (CN)
- XinHua Hospital (CN)
- International Peace Maternity & Child Health Hospital (CN)
- Shanghai Children's Hospital (CN)
Publication Details
- Journal
- Communications Medicine
- Published
- 2025-08-25
- DOI
- https://doi.org/10.1038/s43856-025-01103-2
- Primary Topic
- Pregnancy and preeclampsia studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Shanghai Municipal Health Commission
- Science and Technology Commission of Shanghai Municipality