Retinal glial activation in diabetic retinopathy: therapeuticimpact of multikinase inhibition with sorafenib

Conclusions: Sorafenib attenuates retinal glial activation and neuroinflammatory changes in experimental diabetic retinopathy, suggesting its potential as a neuroprotective and antifibrotic agent. Targeted kinase inhibition may represent a promising adjunct strategy in early-stage disease management.

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Publication Details

Journal
Wiadomości Lekarskie
Published
2025-07-30
DOI
https://doi.org/10.36740/wlek/208991
Primary Topic
Retinal Diseases and Treatments
Type
article
Field-Weighted Citation Impact
0.00
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article

Retinal glial activation in diabetic retinopathy: therapeuticimpact of multikinase inhibition with sorafenib

K.O. Usenko, С. В. Зябліцев, Olena O. Dyadyk, Danylo I Yevstifeiev et al.
Wiadomości Lekarskie
Retinal Diseases and Treatments
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Retinal glial activation in diabetic retinopathy: therapeuticimpact of multikinase inhibition with sorafenib

K.O. Usenko, С. В. Зябліцев, Olena O. Dyadyk, Danylo I Yevstifeiev, Kateryna I. Popova
article en

Abstract

Conclusions: Sorafenib attenuates retinal glial activation and neuroinflammatory changes in experimental diabetic retinopathy, suggesting its potential as a neuroprotective and antifibrotic agent. Targeted kinase inhibition may represent a promising adjunct strategy in early-stage disease management.

Wiadomości LekarskieVol. 78(7)
Shupyk National Healthcare University of Ukraine (UA), Bogomolets National Medical University (UA)
Openalex Percentile: Top 67%
Retinal Diseases and Treatments
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