State of extracellular matrix in testicular embryonal carcinoma

Conclusions: MMP-1, MMP-3 and MMP-9 are involved in carcinogenesis already at the early stages of embryonal carcinoma and at the transition to late stages there is an increase of their synthesis, what proves their significant role in the destruction of extracellular matrix, invasion and metastatic process. Studied MMPs can be regarded as a prognostic factors of the embryonal carcinoma course as well as a potentially important therapeutic targets.