Research progress of psychological intervention assisted gold nanoparticles drug delivery in the treatment of triple-negative breast cancer patients

Objective: Breast cancer represents the most prevalent malignant tumor among women worldwide. Among the subtypes of breast cancer, triple-negative breast cancer (TNBC) exhibits the highest rates of recurrence and mortality. Early diagnosis and effective treatment play a crucial role in delaying the progression of TNBC, prolonging patient survival, and enhancing the quality of life. Therapeutic strategies that leverage gold nanoparticles for targeted drug delivery show significant potential in improving outcomes for patients with TNBC, and adjuvant therapy with early psychological intervention for patients has also attracted much attention. This paper reviews the current advancements in the application of psychological intervention combined with gold nanoparticles in targeted drug delivery and treatment strategies for TNBC, providing a theoretical framework for their clinical application in managing this aggressive breast cancer subtype. Methods: Literature in this article was obtained primarily by searching the PubMed database. We used keywords to search articles: breast cancer, triple-negative breast cancer, nanoparticles, gold nanoparticles, drug delivery, psychological intervention, drug therapy. Results: We found that targeted drug delivery with gold nanoparticles was significantly effective in the treatment of TNBC patients, but psychological intervention assisted targeted drug delivery with gold nanoparticles was significant for improving the survival time and quality of life of patients. Conclusion: Therapeutic strategies for targeted drug delivery with gold nanoparticles are increasing and technology is becoming more and more mature. Targeted drug delivery with gold nanoparticles combined with psychological intervention can effectively delay the process of disease development while improving the survival beliefs of patients with TNBC.