Revisiting the Triglyceride–Glucose Index in Parkinson’s Disease: Risk Ractor or Disease Marker?

Cohort Study" 1 .The authors demonstrate that a higher triglyceride-glucose (TyG) index is associated with an increased risk of Parkinson's disease (PD), particularly in non-diabetic individuals.This large, population-based study from South Korea highlights insulin resistance as a potentially modifiable factor in the pathogenesis of PD and suggests the utility of simple and cost-effective measures of fasting triglycerides and glucose as predictive markers to identify atrisk individuals.Intrigued by the observations of this study, we attempted to evaluate the TyG index in our cohort of hospital-patients with PD and healthy controls (HC).These subjects are part of prospective single-centre study -the Young and Late onset Parkinson's disease (YLOPD) study , conducted at the Department of Neurology, National Institute of Mental Health and Neurosciences (NIMHANS), Bangalore, India.While Chang et al, reported an elevated TyG index preceding the onset of PD, we observed the opposite pattern in our cohort of established cases of PD.Among