Clostridioides difficile Infection in Healthy Children After Antibiotic Use: A Report of Two Cases

Although <i>Clostridioides difficile</i> infection (CDI) commonly affects the elderly, hospitalized, or immunocompromised patients with underlying diseases, cases of community-acquired CDIs in previously healthy children have recently been reported. Here, we describe the cases of two healthy children who developed CDI after the use of antibiotics. Patients were administered either high-risk antibiotics for CDI or a combination of multiple low-risk antibiotics. The clinical characteristics of the patients that differentiated CDI from antibiotic-associated diarrhea (AAD) include bloody stools, fever, and an elevated inflammatory response. Even in healthy children with a history of low-risk antibiotic use, CDI should be considered in the differential diagnosis of prolonged diarrhea or bloody stools, highlighting the importance of a thorough antibiotic exposure history.