Complete resolution of urge urinary incontinence following treatment of ADHD with lisdexamfetamine: a case report

This case report describes the complete and sustained resolution of urge urinary incontinence in a 50-year-old woman diagnosed with Attention-Deficit/Hyperactivity Disorder (ADHD), Autism Spectrum Disorder (ASD) Level 1, and complex post-traumatic stress disorder (cPTSD), following initiation of lisdexamfetamine. The patient experienced urge urinary incontinence for years, which resolved entirely within weeks of commencing lisdexamfetamine at a therapeutic dose for ADHD. This clinical observation raises the possibility of a previously unrecognised neuroregulatory effect of stimulant pharmacotherapy on central bladder control mechanisms. This case suggests the need for further investigation into the interplay between neurodevelopmental disorders, psychiatric comorbidity, and lower urinary tract function. No published data to date have identified lisdexamfetamine as a modulator of continence. Limited evidence exists for atomoxetine in paediatric nocturnal enuresis, but stimulant effects on adult urge incontinence remain undocumented.