NSUN2–tRNAVal−CAC-axis-regulated codon-biased translation drives triple-negative breast cancer glycolysis and progression
This study identifies NSUN2 as a critical regulator of TNBC progression through tRNA<sup>Val-CAC</sup> m5C modification and codon-biased translation of glycolysis-related mRNAs. Our findings reveal a novel NSUN2-tRNA<sup>Val-CAC</sup> axis that orchestrates metabolic reprogramming and translational control in TNBC, offering a promising prognostic biomarker and therapeutic target.
Authors
- Juan Huang (ORCID: https://orcid.org/0000-0003-2901-7175)
- Lun‐Quan Sun (ORCID: https://orcid.org/0000-0002-0558-5250)
- Hui Zhao (ORCID: https://orcid.org/0000-0002-9935-1382)
- Ying Ding (ORCID: https://orcid.org/0000-0002-9973-835X)
- Wenlong Wang (ORCID: https://orcid.org/0000-0003-4441-6027)
- Shouman Wang
Institutions
- Central South University (CN)
- Hunan University (CN)
- Hunan Cancer Hospital (CN)
- Third Xiangya Hospital (CN)
- Xiangya Hospital Central South University (CN)
- Huazhong University of Science and Technology (CN)
Publication Details
- Journal
- Cellular & Molecular Biology Letters
- Published
- 2025-08-25
- DOI
- https://doi.org/10.1186/s11658-025-00781-z
- Citations
- 6
- Primary Topic
- RNA modifications and cancer
- Type
- article
- Field-Weighted Citation Impact
- 4.84
Funders
- National Natural Science Foundation of China
- China Postdoctoral Science Foundation